Zeb2 directs EMT-like processes that underlies the glial response to injury
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چکیده
منابع مشابه
Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS.
Innate responses in the CNS are critical to first line defense against infection and injury. Leukocytes migrate to inflammatory sites in response to chemokines. We studied leukocyte migration and glial chemokine expression within the denervated hippocampus in response to axonal injury caused by entorhinodentate lesions. A population of Mac1/CD11b+ CD45high macrophages (distinct from CD45low mic...
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in vertebrates and to determine the molecular and cellular basis for such currents. Methods: We use zebrafish caudal fin as an adult regeneration model. Specific ion flux measurements are done using a non-invasive Ion-Specific Scanning Microprobe coupled with transcriptional profiling and genetic functional analysis. Results: Our data points to an important role for protons (H[+]) during the re...
متن کاملHypoxia-like tissue injury and glial response contribute to Balo concentric lesion development
OBJECTIVE To clarify the pathogenic factors and mechanisms underlying the development of concentric demyelinating lesions in Balo disease. METHODS We conducted serial clinical, MRI, and histopathologic assessments of concentric lesion formation in a case of relapsing Balo disease. RESULTS The patient experienced 2 attacks caused by left parietal and left frontal lesions in 5 years. In MRI f...
متن کاملFrom EMT to HSC to AML: ZEB2 is a cell fate switch.
Objective: This study aims to compare surgical outcome of transanal ileal pouch-anal anastomosis (ta-IPAA) with transabdominal minimal invasive approach in ulcerative colitis (UC), using the comprehensive complication index (CCI). Background: Recent evolutions in rectal cancer surgery led to transanal dissection of the rectum resulting in a better exposure of the distal rectum and presumed bett...
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ژورنال
عنوان ژورنال: Neural Regeneration Research
سال: 2021
ISSN: 1673-5374
DOI: 10.4103/1673-5374.306078